Neuropeptide Y Receptor
NPY receptor
Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.
Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).
Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.
Neuropeptide Y Receptor Isoform Specific Products
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Neuropeptide Y Receptor Inhibitors
(15)
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Neuropeptide Y Receptor Agonists
(71)
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Neuropeptide Y Receptor Antagonists
(62)
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Neuropeptide Y Receptor Activators
(2)
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Neuropeptide Y Receptor Modulators
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Neuropeptide Y Receptor Control
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Neuropeptide Y Receptor Related Products (181)
Related Products (181)
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Antibodies (8)
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Neuropeptide Y Receptor Isoform Comparison
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Npy5r Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09522Npy5r Rat Pre-designed siRNA Set A contains three designed siRNAs for Npy5r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Galanin (1-13)-spantide I
0 ImagesCat. No.: HY-P5765CAS No.: 143868-20-6Galanin (1-13)-spantide I is a chimeric peptide composed of the N-terminal fragment of galanin (amino acids 1-13) and spantide, a known substance P receptor antagonist. Galanin (1-13)-spantide I has a high affinity for spinal galanin receptor (Kd=1.16 nM). Galanin (1-13)-spantide I can be used to study the effects of galanin on feeding behavior.
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NPY Y2 antagonist 2
0 ImagesCat. No.: HY-180406CAS No.: 1262495-12-4NPY Y2 antagonist 2 is a modulator targeting the neuropeptide Y (NPY) receptor Y2, with pKi values of 6.8 nM and 7.2 nM in human and rat brains, respectively, and demonstrating blood-brain barrier penetration. NPY Y2 antagonist 2 shows selectivity for the Y1 and Y5 receptors. NPY Y2 antagonist 2 blocks the negative feedback regulation mediated by the NPY Y2 receptor, thereby increasing endogenous NPY release and enhancing Y1 receptor activation, resulting in the modulation of central neurotransmitter release. NPY Y2 antagonist 2 exhibits moderate in vivo clearance, high free fraction in rat brain, and a favorable brain/plasma ratio and brain exposure. NPY Y2 antagonist 2 is applicable for research in conditions such as mood disorders, anxiety induced by alcohol withdrawal, and social anxiety associated with nicotine withdrawal.
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Galnon
0 ImagesCat. No.: HY-103536CAS No.: 475115-35-6Galnon is a selective and non-peptide agonist of galanin GAL1 and GAL2 receptor, with Kis of 11.7 and 34.1 μM respectively. Galnon exhibits anticonvulsant and anxiolytic effects.
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GW438014A
0 ImagesGW438014A is a selective NPY-Y5 receptor competitive antagonist capable of crossing the blood-brain barrier, with IC50 values of 197 nM and 211 nM against human receptors. GW438014A reverses PYY-mediated inhibition of Forskolin (HY-15371)-induced cAMP production, reduces NPY-induced food intake and nocturnal food intake in rodents, decreases body weight gain and fat mass in Zucker rats, and inhibits centrally mediated feeding behavior. GW438014A can be used in research related to obesity and epilepsy.
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AR-M1896
0 ImagesCat. No.: HY-P1129CAS No.: 367518-31-8AR-M1896 is a GalR2 selective agonist with a binding IC50 of 1.76 nM for rat GalR2. AR-M1896 can be used for the research of acute myocardial infarction and neuropathic pain.
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Neuropeptide SF(mouse,rat)
0 ImagesCat. No.: HY-P1249CAS No.: 230960-31-3Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .
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RFRP-3(human) TFA
0 ImagesCat. No.: HY-P1250ASynonyms: Neuropeptide VF(124-131)(human) TFA; Neuropeptide NPVF (human) TFARFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM.
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CART (55-76), rat
0 ImagesCat. No.: HY-P3692CAS No.: 1815618-15-5CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior.
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Npy1r Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09513Npy1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Npy1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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TC2
0 ImagesCat. No.: HY-P11279TC2 is an efficient GIPR-preferring monomeric quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.47, 2.1, 30, and 55 nM respectively. TC2 exhibits a significant GLP-1R preference, with a significant reduction in β-inhibitory protein 2 (βArr2) recruitment, while maintaining a strong cAMP signal. TC2 can be used for research on obesity and diabetes.
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PD 160170
0 ImagesCat. No.: HY-107724CAS No.: 181468-88-2PD 160170 is a compound developed to inhibit low-risk myelodysplastic syndrome-associated anemia with activities that promote red blood cell transfusion independence and increase hemoglobin.
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Galanin (2-29) (rat)
0 ImagesCat. No.: HY-P1133CAS No.: 141696-11-9Synonyms: Rat galanin(2-29)
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SCH 430765
0 ImagesCat. No.: HY-W782997CAS No.: 405057-30-9SCH 430765 is potent and selective NPY5 receptor antagonist. SCH 430765 can be used for the study of obesity.
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Neuropeptide Y (3-36) (porcine)
0 ImagesCat. No.: HY-P3676CAS No.: 143863-88-1Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.
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Galanin-Like Peptide (human)
0 ImagesCat. No.: HY-P5063CAS No.: 245114-99-2Galanin-Like Peptide (human) is a 60 amino acid neuropeptide. Galanin-Like Peptide (human) plays an important role in the regulation of feeding, body weight and energy metabolism.
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[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat
![[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat](https://file.medchemexpress.com/product_pic/hy-p11411.gif "Click to View [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat Product Detail")
0 ImagesCat. No.: HY-P11411[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat is a fragment analogue of a neuropeptide Y (NPY) with cardiovascular activity. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can induce profound and sustained hypotension in both hypertensive and normotensive rats and its antihypertensive effect is partly attributed to its activity on histamine receptor. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can be used for studying antihypertensive effects.
